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fosFire luminophores Nomenclature

The product code for a luminophore is created using the following sequence of characters

ABCDxWN-nnnn

where –#nnn is the Batch CODE, # will range from A to Z and nnn from 1 to 999.

A = type of lanthanide

  • E = Europium
  • T = Terbium
  • S = Samarium
  • D = Dysprosium
  • Pt = platinum
  • X = other

 

B = ligand structure

  • T = terphenyl
  • B = 1,2 Dibenzyl benze (BHHBCB)
  • C = Carbazole
  • P = pyridine based
  • D = DOTA

 

C = active binding group – the moiety that binds to target

  • C = chlorosulfonate
  • S = succinimide
  • M = maleimide

 

D = conjugate status

  • Dn = dendrimer of stage n
  • Ab = antibody
  • Aa = anti-antibody
  • Ax = carrier of some other type of biomolecule
  • X = not a conjugate

 

W = relative hydrophilic range – the ligand is dissolved in DMF at a concentration of 50 mg/ml and a maximum volume of 20 µL of this solution is added to 1ml of FEB solution.

  • 0 = less than 100 µg/ml (hydrophobic)
  • Range 1 to 8 corresponds to 100 µg/ml to 800 µg/ml (2 µL to 16 µL)
  • 9 = water solubility of ligand exceeds 1 mg/ml

 

N = ligand status / chelated with target ion or not

  • 1 = ligand is chelated with target ion
  • 0 = ligand is pure and requires addition of ion

 

Example, BHHCT as pure ligand, has a chlorosulfonate binding group, is without added Eu3+ and was produced from the first batch A = E; B = T; C = C; D = X; W = 0; N = 0, batch code = A001 then BHHCT has product code ETCX00-A001